1.) Remember the P Limits for your regions. You could lose ships if you accidentally go over the Region Limit.
2.) Remember the per turn P production of your regions. It is the same as the minimum P size to move ships to another region. Having designs that equal that exact amount will allow you to act efficiently. See Supply Units
3.) Regions under attack do not produce ships. Use this to deny an enemy’s production, and keep it in mind when planning your actions. Enemies can deny your production as well.
4.) Regions can only support a capped amount of ships. But, many regions can be attacked from multiple locations, thus an attack force can be much larger than what a region can defend. See Attacking from Multiple Regions
5.) Maximize the number of regions that can build ships. Regions under attack can not build ships, thus you want to control as many ‘safe’ regions as possible, and keep the pressure on other players.
6.) Keep your neighbors in mind. Swap out blueprints for ones that will be effective verse expected opponents.
7.) Work towards your faction’s strengths. Do your best to eliminate players who’s factions can do your faction serious harm.